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South Africa will be looking to add to their ten-game unbeaten run against England when the two nations collide at Twickenham Stadium on Saturday.
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Scotland will be looking to end their November Test series on a high when they play host to Tonga at Pittodrie Stadium in Aberdeen on Saturday.
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Wales will be under mounting pressure to avoid a sixth successive defeat as they chase a first-ever win over New Zealand at the Millennium Stadium on Saturday.
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The world's sixth and seventh best sides will face off in Dublin on Saturday as Ireland host Argentina in the latest November International.
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France and Samoa have made the biggest headlines during the end-of-year international window. On Saturday they go head-to-head in Paris.
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Italy will want to be at their best for a full 80 minutes when they face a rejuvenated Wallabies side in Florence on Saturday.
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